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出願特許(Patent
 論文 (Publication)
2020
N. Morimoto, Y. Okamura, T. Nakazaki, S. Maekawa, H. Wang, T. Aoki, T. Kono, M. Sakai, J. Hikima* ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka Oryzias latipes. Fish and Shellfish Immunology, in press

Y. Tsutsui, T. Onoue, J. Hikima, M. Sakai and T. Kono* Diel variation of CC chemokine gene expression in the Japanese pufferfish Takifugu rubripes. Marine Biotechnology, in press

G. Taira, T. Onoue, J. Hikima, M. Sakai and T. Kono*. Circadian clock components Bmal1 and Clock1 regulate tlr9 gene expression in the Japanese medaka (Oryzias latipes). Fish and Shellfish Immunology, in press

Y. Takahashi, Y. Okamura, N. Morimoto, K. Mihara, S. Maekawa, H. Wang, T. Aoki, T. Kono, M. Sakai and J. Hikima*. Immune responses in the Japanese pufferfish (Takifugu rubripes) head kidney and intestinal cells treated with recombinant interleukin-17A/F1. Fish and Shellfish Immunology, 2020, 103, 143-149.

A. Tsuchiya, A. Nishihara, A. Saeki, Y. Teru, T. Aoki, T. Kono, M. Sakai and J. Hikima*. Comparative analysis of plasmid DNAs from two strains of Photobacterium damselae subs. piscicida from Japan and the United States. Fish Pathology, 2020, 15(1), 18-21.

Y. Okamura, N. Morimoto, D. Ikeda, N. Mizusawa, S. Watabe, H. Miyanishi, Y. Saeki, H. Takeyama, T. Aoki, M. Kinoshita, T. Kono, M. Sakai and J. Hkima*. Interleukin-17AF1 deficiency reduces antimicrobial gene expression and contributes to microbiome alteration in intestines of Japanese medaka (Oryzias latipes). Frontiers in Immunology, 2020, 11, 425.

Y. Okamura, N. Morimoto, S. Sawada, T. Kono, J. Hikima* and M. Sakai. Molecular characterization and expression of two interleukin-17 receptor A genes on different chromosomes in Japanese medaka, Oryzias latipes. Comparative Biochemistry and Physiology, Part B, 240(2020), 110386.

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2019

T. Onoue, G. Nishi, J. Hikima, M. Sakai and T. Kono*
Circadian oscilattion of TNF-a gene expression regulated by clock gene, BMAL1 and CLOCK1 in the Japanese medaka (Oryzias latipes). International Immunopharmacology, 2019, 70, 362-371.

N. Morimoto, M. Kondo, T. Kono, M. Sakai and J. Hikima*
Nonconservation of TLR5 activation site in Edwardsiella tarda flagellin decreases expression of interleukin-
and NF-kB genes in Japanese flounder, Paralichthys olivaceus. Fish and Shellfish Immunolgy, 2019, 87, 765-771.

S. Murakami, N. Morimoto, T. Kono, M. Sakai and J. Hikima*
Molecular characterization and expression of the teleost cytosolic DNA sensor genes cGAS, LSm14A, DHX9, and DHX36 in Japanese medaka, Oryzias latipes. Developmental and Comparative Immunology, 2019, 103402.

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2017

T. Kono*, T. Ida, N. Kawahara, F. Watanabe, G. Biswas, T. Sato, K. Mori and M. Miyazato
Identification and immunoregulatory function of neuromedin U (NMU) in the Japanese pufferfish Takifugu rubripes.
Developmental and Comparative Immunology, 2017, 73, 246-256.

J. Hikima*, M. Morita, S. Kinoshita, M. Basu, G. Biswas, T. Kono and M. Sakai. Molecular characterization and expression analysis of tumor necrosis factor alpha-induced protein 3 (TNFAIP3/A20) gene from Japanese pufferfish, Takifugu rubripes. Fish Pathology, 2017, 52(1), 15-22.

T. Mekata, T. Kono, J. Satoh, M. Yoshida, K. Mori, T. Sato, M. Miyazato and T. Ida* (Both authors contributed equally to this work) Purification and characterization of bioactive peptides RYamide and CCHamide in the kuruma shrimp Marsupenaeus japonicas. General and Comparative Endocrinology, 2017, 246, 321-33.

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2016

G. Biswas, H. Kodama, T. Mekata, T. Kono, H. Yokoyama, M. Sakai* and J. Hikima. Detection of Kudoa septempunctata in the Japanese flounder by loop-mediated isothermal amplification (LAMP) targeting the internal transcribed spacer (ITS) regions. Turkish Journal of Fisheries and Aquatic Science, 2016, 16, 623-628.

Y. Suzuki*, T. Kobayashi, M. Nishiyama and T. Kono. Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid. Journal of Bioscience and Bioengineering, 2016, 122, 252-256.

T. Nakanishi*,M. Anraku, R. Suzuki, T. Kono, L. Erickson and S. Kawahara. Novel immunomodulatory effects of phytanic acid and its related substances in mice. Journal of Functional Foods, 2016, 21, 283-289.

T. Morimoto, G. Biswas, R. T. Kono, M. Sakai and J. Hikima*. Immune responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with particulate silica. Fish and Shellfish Immunology, 2016, 49, 84-90.

G. Biswas, R. Nagamine, J. Hikima, M. Sakai and T. Kono*. Inductive immune responses in the Japanese pufferfish (Takifugu rubripes) treated with recombinant IFN-g, IFN-grel, IL-4/13A and IL-4/13B. International Immunopharmacology, 2016, 31, 50-56.

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2015

J. Fall, G. Chakraborty, T. Kono and M. Sakai*.Identification of Vibrio nigripulchritudo from shrimp by species specific PCR analysis of the 16-23S rDNA Intergenic Space (ITS). Academia Journal of Biotechnology, in press

G. Biswas, S. Bilen, T. Kono, M. Sakai, J. Hikima*. Inflammatory immune response by lipopolysaccharide-responsive nucleotide bindingoligomerization domain (NOD)-like receptors in the Japanese pufferfish (Takifugu rubripes). Developmental and Comparative Immunology, 2015, 55, 21-31.

M. Sakai, G. Biswas, T. Kono, J. Hikima and H. Yokoyama*. Detection of Kudoa amamiensis using loop-mediated isothermal amplification (LAMP). Fish Pathology, 2015, 50(3), 119-122.

T. Kono, G. Biswas, J. Fall, T. Mekata, J. Hikima, T. Itami and M. Sakai*.Adjuvant effects of polyI:C and imiquimod on the immunization of kuruma shrimp (Marsupenaeus japonicas) with a recombinant protein, VP28 against white spot syndrome virus. Aquaculture, 2015, 446, 236-241.

G. Biswas, S. Kinoshita, T. Kono, J. Hikima and M. Sakai*. Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): comprehensive genomic identification and expression analysis.Marine Genomics, 2015, 22, 25-36.

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2014

T. Kono J. Fall, H. Korenaga, R. Sudhakaran, G. Biswas, T. Mekata, T. Itami and M. Sakai*.Recombinant VP28 produced by cell-free technique confers protection in kuruma shrimp. (Marsupenaeus japonicus) against white spot syndrome virus. Turkish Journal of Fisheries and Aquatic Sciences, 2014, 14, 547-555.

S. Bilen, G. Biswas, S. Otsuyama, T. Kono, M. Sakai and J. Hikima*. Infalammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome inducing agenet, nigericin. Developmental and Comparative Immunology, 2014, 46, 222-230.

S. Kinoshita, G. Biswas, T. Kono, J. Hikima and M. Sakai*. Presence of two tumor necrosis factor (tnf)-a homologs on different chromosomes of zebrafish (Danio rerio) and medaka (Oryzias latipes). Marine Genomics, 2014, 13, 1-9.

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2013

H. Korenaga, R. Nagamine, M. Sakai, T. Kono*. Expression profile of cytokine genes in Fugu monocytes stimulated with TLR agonists. International Immunopharmacology, 2013, 17, 390-399.

T. Kono*, H. Korenaga. Cytokine gene expression in CD4 positive cells of the Japanese pufferfish Takifugu rubripes. PLOS ONE, 8(6): e66364. doi:10.1371/journal.pone.0066364.

G. Biswas, H. Korenaga, R. Nagamine, H. Takayama, S. Kawahara, S. Takeda, Y. Kikuchi, B. Dashnyam, T. Kono* and M. Sakai*. Cytokine responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells induced with heat-killed probiotics isolated from the Mogolian dairy products. Fish and Shellfish Immunology, 2013, 34, 1170-1177.

M. Inada, K. Kihara, T. Kono, R. Sudhakaran, T. Mekata, M. Sakai, T. Yoshida, T. Itami*. Deciphering of the dual oxidase (Nox family) gene from kuruma shrimp, Marsupenaeus japonicas: full-length cDNA cloning and characterization. Fish and Shellfish Imunology, 2013, 34, 471-485.


R. Nagamine, H. Korenaga, M. Sakai, C. J. Secombes, T. Kono*. Characterization and expression analysis of Th-POK from the Japanese pufferfish, Takifugu rubripes. Comparative Biochemistry and Physiology: Part B: Biochemistry and Molecular Biology, 2013, 164, 124-132.

T. Kono*, H. Takayama, R. Nagamine, H. Korenaga, M. Sakai. Establishment of a multiplex RT-PCR assay for rapid detection of fish cytokines. Veterinary Immunology and Immunopathology, 2013, 151, 90-101.

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2012

T. Wang*, T. Kono, M. M. Monte, H. Kuse, M. M. Costa, H. Korenaga, T. Maehr, M. Husain, M. Sakai, C. J. Secombes. Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor. Molecular Immunology, 2012, 53, 398-409.

G. Biswas, H. Korenaga, H. Takayama, T. Kono, H. Shimokawa, M. Sakai*. Cytokine responses in the common carp, Cyprinus carpio L. treated with baker's yeast extract. Aquaculture, 2012, 356-357, 169-175.


T. Kono*, S. Hamasuna, H. Korenaga, T. Iizasa, R. Nagamine, T. Ida, M. Sakai. The role of neuromedin U during inflammatory response in the common carp. Fish and Shellfish Imunology, 2012, 32, 151-160.

M. Inada, R. Sudhakaran, K. Kihara, J. Nishi, M. Yoshimine, T. Mekata, T. Kono, M. Sakai, T. Yoshida, T. Itami. Molecular cloning and characterization of the NADPH oxidase from the kuruma shrimp, Marsupenaeus japonicus, Early gene up-regulation after Vibrio penaeicida and poly(IC) stimulation in vitro. Molecular and Cellular Probes, 2012, 26, 29-41.

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2011

T. Mekata, S. Okugawa, M. Inada, M. Yoshimine, J. Nishi, T. Kono, M. Sakai, T. Itami and R. Sudhakaran*. Class B scavenger receptor; Croquemort from kuruma shrimp Marsupenaeus japonicas: Molecular cloning and characterization. Molecular and Cellular Probes, 2011, 25, 94-100.

R. Sudhakaran, T. Mekata, T. Kono, M. Inada, S. Okugawa, M. Yoshimine, T. Yoshida, M. Sakai, T. Itami*. Double-stranded RNA-mediated silencing of the white spot syndrome virus VP28 gene in kuruma shrimp, Marsupenaeus japonicas. Aquaculture Research, 2011, 42, 1153-1162.


T. Kono*
, H. Korenaga and M. Sakai.
Genomics of fish IL-17 ligand and receptors: A review.
Fish and Shellfish Immunology, 2011, 31, 635-643.

Y. Suzuki, T. Suzuki, T. Kono, T. Mekata, M. Sakai and T. Itami*. The concentration of white spot disease virus for its detection in sea water using a combined ferric colloid adsorption and foam separation-based method. Journal of Virological Methods, 2011, 173, 227-232.

J. Fall, G. Chakraborty, T. Kono, M. Maeda, Y. Suzuki, T. Itami and M. Sakai*, Quantitative loop-mediated isothermal amplification method for the detection of Vibrio nigripulchritudo in shrimp. Fisheries Science, 2011, 77, 129-134.


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2010

J. Fall, T. Kono, T. Mahmoud, T.Itami, and M.Sakai*. Expression of innate immune-related genes of Kuruma shrimp, Marsupenaeus japonicas challenged with Vibrio nigripulchritudo. African Journal of Microbiology Research, 2010, 4, 2426-2433.

T. Mahmoud, T. Kono and M. Sakai*. Cloning, characterization, and expression analysis of Toll-like receptor-7 cDNA from common carp, Cyprinus carpio L. Comparative Biochemistry and Physiology. Part D, Genomic & Proteomics, 2010,5,245-255

R. Sogabe, Rudd Widjen, T. Kono, Anuj Tyagi, Trudy Hermsen, Indrani Karunasagar, M. Sakai, M. Lidy Verburg-van Kemenade and Ram Savan*. Common carp have two subclass of bonyfish specific antibody IgZ showing differential expression in response to infection
Developmental and Comparative Immunology, 2010, 34, 1183-1190.

H. Korenaga#, T. Kono# and M. Sakai*.
Isolation of seven IL-17 genes from the Japanese pufferfish Takifugu rubripes. Fish and Shellfish Immunology, 2010, 28, 809-818.
(# Both authors contributed eqally to this work)

M. Inada, T. Mekata, R. Sudhakaran, S. Okugawa, T. Kono, A.M.E.Asely, N.T.H. Linh, T. Yoshida, M. Sakai, T. Yui, T. Itami*. Molecular cloning and characterization of the nitric oxide synthase gene from kuruma shrimp, Marsupenaeus japonicas. Fish and Shellfish Immunology, 2010, 28, 701-711.

T. Mekata, R. Sudhakaran, S. Okugawa, M. Inada, T. Kono, M. Sakai, T. Itami*. A novel gene of tumor necrosis factor ligand superfamily from kuruma shrimp, Marsupenaeus japonicas. Fish and Shellfish Immunology, 2010, 28, 571-578.

M. Tanekhy, S. Matsuda, T. Itano, H. Kawakami, T. Kono and M. Sakai*. Expression of cytokine genes in head kidney and spleen cells of Japanese flounder (Paralichthys olivaceus) infected with Nocardia seriolae. Veterinary Immunolology and Immunopathology, 2010, 134, 178-183.


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2009

M. Tanekhy, T. Kono and M. Sakai*. Expression profile of cytokine genes in the common carp species Cyprinus carpio L. following infection with Aeromonas hydrophila.
European Association of Fish Pathologists, 2009, 29(6), 197-203.

T. Mekata, R. Sudhakaran, T. Kono, K. U-taynapun, S. Kidchakan, Y. Suzuki, M. Sakai and T. Itami*. Real-time reverse transcription loop-mediated isothermal amplification for rapid detection of yellow head virus in shrimp.
Journal of Virological Methods, 2009, 162, 81-87.

H. Watanuki, G. Chakraborty, H. Korenaga, T. Kono, R.B. Shivappa and M. Sakai*. Immunostimulatory effects of natural human interferon-alpha (huIFN-a) on carps Cyprinus carpio L.Veterinary Immunology and Immunopathology, 2009, 131, 273-277.

Y. Kitao, T. Kono, K. Sonoda, R. Savan and M. Sakai*. Characterization and expression analysis of type I interferon in common carp Cyprinus carpio L. Molecular Immunology, 2009, 46, 2548-2556.

T. Kono, K. Sonoda, T. Mekata, T. Itami and M. Sakai*. DNA vaccine against white spot disease virus in kuruma shrimp, Marsupenaeus japonicas. Journal of Fish Diseases, 2009, 44(2), 94-97.

R. Sudhakaran, T. Mekata, T. Kono, K. Supamattaya, G.T.H. Linh, Y. Suzuki, M. Sakai, T. Itami*. A simple non-enzyme method for the preparation of white spot syndrome virus (WSSV) DNA from the haemolymph of Marsupenaeus japonicus using FTA matrix cards.
Journal of Fish Diseases, 2009, 32, 611-617.

A. Ponpornpisit, N. Areechon, T. Kono, Y. Kitao, M. Sakai, M. Endo. Detection of Mycobacteriosis in the guppy, Poecilia reticulate, by a loop-mediated isothermal amplification method.
European Association of Fish Pathologists, 2009, 29(1), 2-9.

M. Sakai*, Dolores V. Baxa, T. Kurobe, T. Kono, R. B. Shivappa, R. P. Hedrick. Detection of Nucleospora salmonis in cutthroat trout (Oncorhynchus clarki) and rainbow trout (Oncorhynchus mykiss) by loop-mediated isothermal amplification. Aquaculture, 2009, 288, 27-31.

Y. Suzuki*, S. Narimatsu, T. Furukawa, T. Mekata, T. Kono, M. Sakai, T. Itami, H. Katayama. Removal of noroviruses from municipal wastewater by foam separation using dispersed air-bubbles and surface-active substance. Separation Science and Technology, 2009, 44, 569-584.

T. Mekata, S. Raja, T. Kono, S. Kidchakan, L. G. T. H. Linh, M. Sakai, T. Itami*. Real-time quantitative LAMP (loop-mediated isothermal amplification) as a simple method for detecting white spot syndrome virus. Letters in Applied Microbiology, 2009, 48, 25-32.

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2008

R
. Sudhakaran, T. Mekata, T. Kono, K. Supamattaya, G.T.H. Linh, M. Sakai; T. Itami*. Rapid detection and quantification of infectious hypodermal and hematopoietic necrosis virus (IHHNV) by real-time loop-mediated isothermal amplification. Fish Pathology, 2008, 43(4), 170-173.

J. Fall, G. Chakraborty, T. Kono, M. Maeda, T. Itami, M. Sakai*. Establishment of loop-mediated isothermal amplification method (LAMP) for the detection of Vibrio nigripulchritudo in shrimp. FEMS Microbiology Letters, 2008, 288, 171-177.

T. Itano, H. Kawakami, T. Kono, M. Sakai*. Estimation of the time for Nocardia seriolae infection of cultured yellowtail. 血清抗体価測定による養殖ブリのNocardia seriolae感染時期の推定 Fish Pathology (in Japanese), 2008, 43(2), 86-88.

T. Kono, Y. Kitao, K. Sonoda, R. Nomoto, T. Mekata, M. Sakai*. Identification and expression analysis of ghrelin gene in common carp Cyprinus carpio L. Fisheries Science, 2008, 74, 603-612.

T. Kono, S. Bird, K. Sonoda, R. Savan, C. J. Secombes, M. Sakai. Characterization and expression analysis of an interleukin-7 homologue in the Japanese pufferfish, Takifugu rubripes. FEBS Journal, 2008, 275, 1213-1226.

T. Mekata, T. Kono, T. Yoshida, M. Sakai, T. Itami*. Identification of cDNA encoding Toll receptor, MjToll gene from kuruma shrimp, Marsupenaeus japonicas. Fish and Shellfish Immunology, 2008, 24, 122-133.

R. B. Shivappa*, R. Savan, T. Kono, M. Sakai, G. Kurath, J.F. Levine.
Detection of spring viremia of carp virus (SVCV) by loop mediated isothermal amplification (LAMP) in koi carp (Cyprinus carpio). Journal of Fish Diseases, 2008, 31(4), 249-258.

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2007

T. Itano, H. Kawakami, M. Sakashita, T. Kono, M. Sakai.
Efficacy of orally administered streptomycin for the treatment of nocardiosis in yellowtail Seriola quinqueradiata. European Association of Fish Pathologists , 2007, 27(2), 83-87.


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2006

T. Itano, N. Nakaoka, H. Kawakami, T. Kono, M. Sakai*.
Comparison of sensitivity between yellowtail Seriola quinqueradiata and red sea bream Pagrus major to Nocardia seriolae. Fish Pathology, 2006, 41(4), 135-139.

T. Itano, H. Kawakami, T. Kono, M. Sakai*.
Live vaccine trials against nocardiosis in yellowtail Seriola quinqueradiata. Aquaculture, 2006, 261, 1175-1180.

T. Itano, H. Kawakami, T. Kono, M. Sakai*.
Experimental induction of nocardiosis in yellowtail, Seriola quinqueradiata Temminck & Schlegel by artificial challenge. Journal of Fish Diseases, 2006, 29, 529-534.

T. Mekata, T. Kono, R. Savan, M. Sakai, J. Kasornchandra, T. Yoshida, T. Itami*.
Detection of yellow head virus in shrimp by loop-mediated isothermal amplification (LAMP). Journal of Virological Methods, 2006, 135(2), 151-156.

T. Kono, J. Zou, S. Bird, R. Savan M. Sakai and C. J. Secombes*. Identification and expression analysis of lymphotoxin-beta like homologues in rainbow trout Oncorhynchus mykiss. Molecular Immunology, 2006, 43, 1390-1401.

T. Itano, H. Kawakami, T. Kono and M. Sakai*. Detection of fish nocardiosis by loop-mediated isothermal amplification. Journal of Applied Microbiology, 2006, 100(6), 1381-1387.

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2005

R. Savan, T. Kono, T. Itami M. Sakai*. Loop mediated isothermal amplification (LAMP): an emerging technology for detection of fish and shellfish pathogens. Journal of Fish Diseases, 2005, 28, 573-581.

H. Sakata, R. Savan, R. Sogabe, T. Kono, K. Taniguchi, I. Gunimaladevi, A. C. Tassakka, M. Sakai*. Cloning and analysis of non-specific cytotoxic cell receptor (NCCRP)-1 from common carp Cyprinus carpio L. Comparative Biochemistry and Physiology-C, 2005, 140, 287-294.

S. Bird, J. Zou, R. Savan, T. Kono, M. Sakai, J. Woo, C. Secombes*. Characterisation and expression analysis of an interleukin 6 homologue in the Japanese pufferfish, Fugu rubripes. Developmental and Comparative Immunology, 2005, 29, 775-789.

R. Savan, T. Kono, D. Igawa, M. Sakai*. A novel tumor necrosis factor (TNF) gene present along with TNF alpha in tandem on the same chromosome in teleosts. Immunogenetics, 2005, 57, 140-150.

M. Sakai, T. Kono, A.C.M.A.R. Tassaka, A. Ponpornpisit, N. Areechon, T. Katagiri, T. Yoshida, M. Endo*. Characterization of a Mycobacterium sp. isolated from guppy Poecilia reticulata, using 16S ribosomal RNA and its internal transcribed spacer sequences. Bulletin of the European Association of Fish Pathologists, 2005, 25(2), 62-67.

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2004

R. Savan, T. Kono, H. Sakata, M. Sakai*. Expressed sequence tag analyses of common carp, Cyprinus carpio L. 
Marine Biotechnology, 2004, 6, S418-S422.

T. Kono, H. Kuragasaki, R. Savan, A.C.M.A.R. Tassakka, M. Sakai*. Expression analysis of immune-related genes in carp Cyprinus carpio L. Marine Biotechnology, 2004, 6, S123-S127.

I. Gunimaladevi, T. Kono, Venugopal M.N, M. Sakai*. Detection of koi herpesvirus in common carp Cyprinus carpio L., by loop- mediated isothermal amplification. Journal of Fish Disease, 2004, 27, 583-589
.

T. Kono, M. Sakai*. Molecular cloning of a novel preproadrenomedullin gene from common carp Cyprinus carpio L. and its expression. General and Comparative Endocrinology, 2004, 138(1), 78-88.

T. Kono, R. Savan, M. Sakai, T. Itami*. Detection of white spot syndrome virus (WSSV) in shrimp by loop-mediated isothermal amplification. Journal of Virological Methods, 2004, 115, 59-65.

T. Kono, A. Ponpornpisit, M. Sakai*. The analysis of expressed genes in head kidney of common carp Cyprinus carpio L. stimulated with peptidoglycan. Aquaculture, 2004, 235(1-4), 37-52.


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2003

H. Kawano, T. Kono, H. Watanuki, R. Savan, M. Sakai*. Analysis of genes expressed in head kidney of common carp Cyprinus carpio L treated with cortisol.
Comparative Biochemistry and Physiology, 2003, 136(4), 875-886.

T. Kono, M. Sakai*.
Molecular cloning of a novel bactericidal permeability-increasing protein / lipopolysaccharide-binding protein (BPI / LBP) from common carp Cyprinus carpio L. and its expression. Molecular Immunology, 2003, 40, 269-278.

R. Savan, T. Kono, A. Aman, M. Sakai*. Isolation of a novel CXC-chemokine in common carp (Cyprinus carpio L.). Molecular Immunology, 2003, 39(13), 829-834.

T. Kono, R. Kusuda, E. Kawahara, M. Sakai*. The analysis of immune responses of a novel CC-chemokine gene from Japanese flounder Paralichthys olivaceus.
Vaccine, 2003, 21(5-6), 446-457.

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2002

T. Kono
, R. Kusuda, E. Kawahara, M. Sakai*. The phagocytic activity of leucocyte in Japanese flounder, Paralichthys olivaceus, by chemokine gene injection using expression vector. Fisheries Science, 2002, 68(SupplementU), 1229-1230.

T. Kono, T. Ooyama, S.C. Chen, M. Sakai*. Sequencing of 16S-23S rRNA internal transcribed spacer and their application in the identification of Nocardia seriolae by polymerase chain reaction. Aquaculture Research, 2002, 33(14), 1195-1197.

T. Kono, K. Fujiki, M. Nakao, T. Yano, M. Endo, M. Sakai*. The immune responses of carp, Cyprinus carpio, injected with carp interleukin-1b gene. The Journal of Interferon and Cytokine Research, 2002, 22(4), 413-419.

T. Kono, H. Watanuki, M. Sakai*. The activation of interleukin-1b in serum of common carp, Cyprinus carpio L., injected with peptidoglycan. Aquaculture, 2002, 212(1-4), 1-10.

T. Kono, K. Okamoto, M. Sakai*. Analysis of expressed sequence tags from a yellowtail Seriola quinqueradiata head kidney cDNA library. Aquaculture Research, 2002, 33, 291-297.

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2001

T. Kono, M. Sakai*. The analysis of expressed genes in the kidney of Japanese flounder, Paralichthys olivaceus, injected with the immunostimulant peptidoglycan. Fish & Shellfish Immunology, 2001, 11(4), 357-366.

ページ上部へ
2000

T. Kono
*, M. Sakai, E. Kawahara. Induction of auto-antibodies by injection of allogeneic lens proteins in the eel, Anguilla japonica. Journal of Applied Ichthyology, 2000, 16, 285-286.

T. Kono, M. Sakai*, S.E. LaPatra. Expressed sequence tag analysis of kidney and gill tissues from rainbow trout (Oncorhynchus mykiss) infected with infectious hematopoietic necrosis virus. Marine Biotechnology, 2000, 2, 493-498.


ページ上部へ
1999

H. Kawakami, K. Suzukawa, H. Yamashita, Y. Kohno, T. Kono, M.Sakai*. Mass mortality of wild largescale blackfish Girella punctata caused by Photobacterium damsela subsp. Piscicida.
Fish Pathology, 1999, 34(2), 87-88.

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 出願特許 (Patent)
発明の名称:サイトカイン遺伝子を利用したマルチプレックスRT-PCRによる魚類健康診断法
発明者:河野智哉、高山博章
出願人:国立大学法人宮崎大学
特願2011-191778

発明の名称:LAMP法による急性ウイルス血症原因ウイルスの検出方法及び検出試薬キット
発明者:酒井正博、伊丹利明、河野智哉
出願人:国立大学法人宮崎大学
特願2011-50110

発明の名称:甲殻類急性ウイルス血症に対するワクチン
発明者:酒井正博、伊丹利明、河野智哉
出願人:国立大学法人宮崎大学
特願2009-162802

発明の名称:
LAMP法による甲殻類病原性ウイルスの検出方法及び検出試薬キット
発明者:酒井正博、伊丹利明、河野智哉、米加田徹
出願人:国立大学法人宮崎大学
特願2008-027938

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