研究業績

Masuda Y, Rakib TM, Akter L, Nakagawa K, Naitou K, Saito A, Yamaguchi R, Matsumoto Y. Nanopore sequencing-based measurement of paramyxovirus RNA editing reveals virus-specific differences in editing efficiency of mRNA, antigenome and genome. Virology. 2025; 609:110572. https://doi.org/10.1016/j.virol.2025.110572
Mekata H, Yamamoto M, Kaneko Y, Yamada K, Okabayashi T, Saito A. Urine of Cats with Severe Fever with Thrombocytopenia Syndrome: A Potential Source of Infection Transmission. Pathogens. 2025; 14（3）. https://doi.org/10.3390/pathogens14030254
Kosaka AH, Huang CY, Lu ZY, Hsing HZ, Choonnasard A, Ringo RS, Chuang KP, Saito A. Divergent Effects of Circoviridae Capsid Proteins on Type I Interferon Signaling. Pathogens. 2025; 14（1）. https://doi.org/10.3390/pathogens14010068
Yamamoto J, Deguchi H, Sumiyoshi T, Nakagami K, Saito A, Miyanishi H, et al. Accumulation and Phagocytosis of Fluorescently Visualized Macrophages Against Edwardsiella piscicida Infection in Established mpeg1.1-Transgenic Japanese Medaka （Oryzias latipes）. Mar Biotechnol （NY）. 2024; 26（4）:658-671. https://doi.org/10.1007/s10126-024-10333-9
Ringo RS, Choonnasard A, Okabayashi T, Saito A. Conserved Antagonization of Type I Interferon Signaling by Arterivirus GP5 Proteins. Viruses. 2024; 16（8）. https://doi.org/10.3390/v16081240
Lee J, Naoe Y, Bang U, Nakagama Y, Saito A, Kido Y, Hotta A. Neutralization sensitivity of SARS-CoV-2 Omicron variants FL.1 and GE.1 by therapeutic antibodies and XBB sera. Virology. 2024; 595:110067. https://doi.org/10.1016/j.virol.2024.110067
Choonnasard A, Shofa M, Okabayashi T, Saito A. Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling. Int J Mol Sci. 2024; 25（7）. https://doi.org/10.3390/ijms25073753
Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism. iScience. 2024; 27（3）:109107. https://doi.org/10.1016/j.isci.2024.109107
Tanaka YL, Shofa M, Butlertanaka EP, Niazi AM, Hirai T, Mekata H, Saito A. Generation of a Porcine Cell Line Stably Expressing Pig TMPRSS2 for Efficient Isolation of Swine Influenza Virus. Pathogens. 2023; 13（1）. https://doi.org/10.3390/pathogens13010018
Shofa M, Saito A. Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation. PLoS One. 2023; 18（11）:e0289863. https://doi.org/10.1371/journal.pone.0289863
Uriu K, Ito J, Kosugi Y, Tanaka YL, Mugita Y, Guo Z, Hinay AA Jr, Putri O, Kim Y, Shimizu R, Begum MM, Jonathan M, Saito A, Ikeda T, Sato K. Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant. Lancet Infect Dis. 2023; 23（11）:e460-e461. https://doi.org/10.1016/S1473-3099（23）00575-3
Kimura I, Yamasoba D, Nasser H, Ito H, Zahradnik J, Wu J, Fujita S, Uriu K, Sasaki J, Tamura T, Suzuki R, Deguchi S, Plianchaisuk A, Yoshimatsu K, Kazuma Y, Mitoma S, Schreiber G, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Takaori-Kondo A, Ito J, Shirakawa K, Takayama K, Irie T, Hashiguchi T, Nakagawa S, Fukuhara T, Saito A, Ikeda T, Sato K. Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics. J Virol. 2023; 97（10）:e0101123. https://doi.org/10.1128/jvi.01011-23
Silva BBI, Chen JY, Villanueva BHA, Lu ZY, Hsing HZ, Montecillo AD, Shofa M, Minh H, Chuang JP, Huang HY, Saito A, Chuang KP. Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan. Viruses. 2023; 15（10）. https://doi.org/10.3390/v15102128
Shofa M, Ohkawa A, Kaneko Y, Saito A. Conserved use of the sodium/bile acid cotransporter （NTCP） as an entry receptor by hepatitis B virus and domestic cat hepadnavirus. Antiviral Res. 2023; 217:105695. https://doi.org/10.1016/j.antiviral.2023.105695
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Sci Transl Med. 2023; 15（711）:eadi2623. https://doi.org/10.1126/scitranslmed.adi2623
Shofa M, Okamura T, Urano E, Matsuura Y, Yasutomi Y, Saito A. Repeated Intravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge. Int J Mol Sci. 2022; 23（22）. https://doi.org/10.3390/ijms232214002
Kaneko C, Saito A, Inagaki H, Sugiyama H, Mazimpaka E, Fujimoto S, Okabayashi T. Rapid inactivation of Dabie bandavirus （SFTSV） by irradiation with deep-ultraviolet light-emitting diode. J Med Virol. 2022; 94（7）:3438-3441. https://doi.org/10.1002/jmv.27698
Saito A, Tamura T, Zahradnik J, Deguchi S, Tabata K, Anraku Y, Kimura I, Ito J, Yamasoba D, Nasser H, Toyoda M, Nagata K, Uriu K, Kosugi Y, Fujita S, Shofa M, Begum MM, Shimizu R, Oda Y, Suzuki R, Ito H, Nao N, Wang L, Tsuda M, Yoshimatsu K, Kuramochi J, Kita S, Sasaki-Tabata K, Fukuhara H, Maenaka K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Ueno T, Schreiber G, Takaori-Kondo A, Shirakawa K, Sawa H, Irie T, Hashiguchi T, Takayama K, Matsuno K, Tanaka S, Ikeda T, Fukuhara T, Sato K. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant. Cell Host Microbe. 2022; 30（11）:1540-1555.e15. https://doi.org/10.1016/j.chom.2022.10.003
Meng B, Abdullahi A, Ferreira IATM, Goonawardane N, Saito A, et al. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity. Nature. 2022; 603（7902）:706-714. https://doi.org/10.1038/s41586-022-04474-x
Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature. 2022; 602（7896）:300-306. https://doi.org/10.1038/s41586-021-04266-9
Yoshida T, Takemoto H, Sakamaki T, Tokuyama N, Hart J, Hart T, Dupain J, Cobden A, Mulavwa M, Hashimoto C, Isaji M, Kaneko A, Enomoto Y, Sato E, Kooriyama T, Miyabe-Nishiwaki T, Suzuki J, Saito A, Furuichi T, Akari H. Prevalence of antibodies against human respiratory viruses potentially involving anthropozoonoses in wild bonobos. Primates. 2021; 62（6）:897-903. https://doi.org/10.1007/s10329-021-00935-5
Inagaki H, Saito A, Sugiyama H, Okabayashi T, Fujimoto S. Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation. Emerg Microbes Infect. 2020; 9（1）:1744-1747. https://doi.org/10.1080/22221751.2020.1796529
Sultana T, Mamede JI, Saito A, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ, Shioda T. Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid. J Virol. 2019; 93（23）:e00986-19. https://doi.org/10.1128/JVI.00986-19
Shimizu H, Saito A, Mikuni J, Nakayama EE, Koyama H, Honma T, Shirouzu M, Sekine SI, Shioda T. Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. PLoS Negl Trop Dis. 2019; 13（11）:e0007894. https://doi.org/10.1371/journal.pntd.0007894
Suzuki K, Phadungsombat J, Nakayama EE, Saito A, Egawa A, Sato T, Rahim R, Hasan A, Lin MY, Takasaki T, Rahman M, Shioda T. Genotype replacement of dengue virus type 3 and clade replacement of dengue virus type 2 genotype Cosmopolitan in Dhaka, Bangladesh in 2017. Infect Genet Evol. 2019; 75:103977. https://doi.org/10.1016/j.meegid.2019.103977
Suzuki K, Nakayama EE, Saito A, Egawa A, Sato T, Phadungsombat J, Rahim R, Hasan A, Iwamoto H, Rahman M, Shioda T. Evaluation of novel rapid detection kits for dengue virus NS1 antigen in Dhaka, Bangladesh, in 2017. Virol J. 2019; 16（1）:102. https://doi.org/10.1186/s12985-019-1204-y
Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing. J Virol. 2019; 93（16）:e00706-19. https://doi.org/10.1128/JVI.00706-19
Saito A, Ode H, Nohata K, Ohmori H, Nakayama EE, Iwatani Y, Shioda T. HIV-1 is more dependent on the K182 capsid residue than HIV-2 for interactions with CPSF6. Virology. 2019; 532:118-126. https://doi.org/10.1016/j.virol.2019.04.012
Fischer DK, Saito A, Kline C, Cohen R, Watkins SC, Yamashita M, Ambrose Z. CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes. J Virol. 2019; 93（9）:e00214-19. https://doi.org/10.1128/JVI.00214-19