Research Achievements

Since 2019 (#: first author, *: corresponding author)

  1. Kato NX, Dosaka H, Adachi Y, Kaneko Y, Hirai T, Sekiguchi S, Fuke N, Saito A*. Virological and pathological characterization of an outbreak of domestic cat hepatitis B virus infection in a cat shelter in Japan. J Vet Med Sci. 2026 Apr 7. https://doi.org/10.1292/jvms.26-0138.
  2. Abe H, Kato NX, Tanabe M, Shimabukuro T, Hashimoto S, Hirai T, Fuke N, Saito A*. Malignant epithelial tumors associated with Felis catus papilloma virus type 3 and type 4 infections at distinct anatomical sites in a domestic cat. J Vet Med Sci. 2026 Mar 24. https://doi.org/10.1292/jvms.25-0517.
  3. Fukushima YV, Saito N, Mekata H, Saito A*. Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat’s body surface. Sci Rep. 2026;16(1):4101. https://doi.org/10.1038/s41598-026-37655-z.
  4. Matsuura R, Saito A, Nagata F, Fukushi N, Matsumoto Y, Fukushima T, Fujimoto K, Kozaki M, Somei J, Aida Y. TiO2 Photocatalyst Inactivates Highly Pathogenic Avian Influenza Virus and H1N1 Seasonal Influenza Virus via Multi-Antiviral Effects. Catalysts. 2026; 16(2):168. https://doi.org/10.3390/catal16020168
  5. Dosaka H, Kato NX, Taga K, Yamamoto S, Kondo K, Ringo RS, Kaneko Y, Hirai T, Saito A*, Fuke N. Distribution of domestic cat hepatitis B virus in cholangiocarcinoma and non-neoplastic liver tissue. J Vet Med Sci. 2026;88(3):458-462. https://doi.org/10.1292/jvms.25-0372.
  6. Zhang H, Saito A*. Development of a Porcine Cell Line Stably Expressing Ephrin-B2 for Nipah Virus Research and Diagnostic Testing. Microbiol Immunol. 2026 Jan;70(1):36-46. https://doi.org/10.1111/1348-0421.70022
  7. Ullah S, Notsu K, Saito A, Okabayashi T, Mekata H, Shiokawa M, Aoki H, Sekiguchi S. Development of multiplex reverse-transcription digital PCR assay for co-detection of bovine leukemia virus and bovine viral diarrhea virus in cattle. J Virol Methods. 2026 Feb;340:115298. https://doi.org/10.1016/j.jviromet.2025.115298
  8. Nakata Y, Uriu K, Hashimoto R, Yamamoto T; Genotype to Phenotype Japan (G2P-Japan) Consortium; Saito A, Sato K, Takayama K. Mpox virus replicates in lung organoids without significantly affecting their cellular function. Biochem Biophys Rep. 2025;44:102326. https://doi.org/10.1016/j.bbrep.2025.102326.
  9. Nakata Y, Yamasaki M, Watanabe Y, Uriu K, Hashimoto R, Yamamoto T; Genotype to Phenotype Japan (G2P-Japan) Consortium; Sato K, Saito A*, Takayama K. Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling. iScience. 2025;28(12):114105. https://doi.org/10.1016/j.isci.2025.114105.
  10. Jin Z, Taguwa S, Hirano J, Uemura K, Ono C, Saito A, Okabayashi T, Maeda Y, Kinoshita T, Matsuura Y. SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase. J Virol. 2025 Sep 23;99(9):e0022125. https://doi.org/10.1128/jvi.00221-25
  11. Shofa M, Fukushima YV, Saito A*. Conserved Yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X Proteins. Int J Mol Sci. 2025 Jul 15;26(14). https://doi.org/10.3390/ijms26146786
  12. Masuda Y, Rakib TM, Akter L, Nakagawa K, Naitou K, Saito A, Yamaguchi R, Matsumoto Y. Nanopore sequencing-based measurement of paramyxovirus RNA editing reveals virus-specific differences in editing efficiency of mRNA, antigenome and genome. Virology. 2025; 609:110572. https://doi.org/10.1016/j.virol.2025.110572
  13. Mekata H, Yamamoto M, Kaneko Y, Yamada K, Okabayashi T, Saito A. Urine of Cats with Severe Fever with Thrombocytopenia Syndrome: A Potential Source of Infection Transmission. Pathogens. 2025; 14（3）. https://doi.org/10.3390/pathogens14030254
  14. Kosaka AH, Huang CY, Lu ZY, Hsing HZ, Choonnasard A, Ringo RS, Chuang KP, Saito A*. Divergent Effects of Circoviridae Capsid Proteins on Type I Interferon Signaling. Pathogens. 2025; 14（1）. https://doi.org/10.3390/pathogens14010068
  15. Yamamoto J, Deguchi H, Sumiyoshi T, Nakagami K, Saito A, Miyanishi H, et al. Accumulation and Phagocytosis of Fluorescently Visualized Macrophages Against Edwardsiella piscicida Infection in Established mpeg1.1-Transgenic Japanese Medaka （Oryzias latipes）. Mar Biotechnol （NY）. 2024; 26（4）:658-671. https://doi.org/10.1007/s10126-024-10333-9
  16. Samune Y, Saito A, Sasaki T, Koketsu R, Srimark N, Phadungsombat J, Yokoyama M, Kotani O, Sato H, Yamanaka A, Haga S, Okamoto T, Kurosu T, Nakayama EE, Shioda T. Genetic regions affecting the replication and pathogenicity of dengue virus type 2. PLoS Negl Trop Dis. 2024;18(1):e0011885. https://doi.org/10.1371/journal.pntd.0011885.
  17. Ringo RS, Choonnasard A, Okabayashi T, Saito A*. Conserved Antagonization of Type I Interferon Signaling by Arterivirus GP5 Proteins. Viruses. 2024; 16（8）. https://doi.org/10.3390/v16081240
  18. Lee J, Naoe Y, Bang U, Nakagama Y, Saito A, Kido Y, Hotta A. Neutralization sensitivity of SARS-CoV-2 Omicron variants FL.1 and GE.1 by therapeutic antibodies and XBB sera. Virology. 2024; 595:110067. https://doi.org/10.1016/j.virol.2024.110067
  19. Choonnasard A, Shofa M, Okabayashi T, Saito A*. Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling. Int J Mol Sci. 2024; 25（7）. https://doi.org/10.3390/ijms25073753
  20. Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A*, Yoshimura SH. Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism. iScience. 2024; 27（3）:109107. https://doi.org/10.1016/j.isci.2024.109107
  21. Tanaka YL, Shofa M, Butlertanaka EP, Niazi AM, Hirai T, Mekata H, Saito A*. Generation of a Porcine Cell Line Stably Expressing Pig TMPRSS2 for Efficient Isolation of Swine Influenza Virus. Pathogens. 2023; 13（1）. https://doi.org/10.3390/pathogens13010018
  22. Shofa M, Saito A*. Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation. PLoS One. 2023; 18（11）:e0289863. https://doi.org/10.1371/journal.pone.0289863
  23. Uriu K, Ito J, Kosugi Y, Tanaka YL, Mugita Y, Guo Z, Hinay AA Jr, Putri O, Kim Y, Shimizu R, Begum MM, Jonathan M, Saito A, Ikeda T, Sato K. Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant. Lancet Infect Dis. 2023; 23（11）:e460-e461. https://doi.org/10.1016/S1473-3099（23）00575-3
  24. Kimura I, Yamasoba D, Nasser H, Ito H, Zahradnik J, Wu J, Fujita S, Uriu K, Sasaki J, Tamura T, Suzuki R, Deguchi S, Plianchaisuk A, Yoshimatsu K, Kazuma Y, Mitoma S, Schreiber G, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Takaori-Kondo A, Ito J, Shirakawa K, Takayama K, Irie T, Hashiguchi T, Nakagawa S, Fukuhara T, Saito A, Ikeda T, Sato K. Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics. J Virol. 2023; 97（10）:e0101123. https://doi.org/10.1128/jvi.01011-23
  25. Silva BBI, Chen JY, Villanueva BHA, Lu ZY, Hsing HZ, Montecillo AD, Shofa M, Minh H, Chuang JP, Huang HY, Saito A*, Chuang KP. Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan. Viruses. 2023; 15（10）. https://doi.org/10.3390/v15102128
  26. Shofa M, Ohkawa A, Kaneko Y, Saito A*. Conserved use of the sodium/bile acid cotransporter （NTCP） as an entry receptor by hepatitis B virus and domestic cat hepadnavirus. Antiviral Res. 2023; 217:105695. https://doi.org/10.1016/j.antiviral.2023.105695
  27. Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A*, Okamoto T. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Sci Transl Med. 2023; 15（711）:eadi2623. https://doi.org/10.1126/scitranslmed.adi2623
  28. Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K; Genotype to Phenotype Japan (G2P-Japan) Consortium; Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nat Commun. 2023;14(1):2800. https://doi.org/10.1038/s41467-023-38435-3.
  29. Ito J, Suzuki R, Uriu K, Itakura Y, Zahradnik J, Kimura KT, Deguchi S, Wang L, Lytras S, Tamura T, Kida I, Nasser H, Shofa M, Begum MM, Tsuda M, Oda Y, Suzuki T, Sasaki J, Sasaki-Tabata K, Fujita S, Yoshimatsu K, Ito H, Nao N, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Kuramochi J, Schreiber G; Genotype to Phenotype Japan (G2P-Japan) Consortium; Saito A, Matsuno K, Takayama K, Hashiguchi T, Tanaka S, Fukuhara T, Ikeda T, Sato K. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant. Nat Commun. 2023;14(1):2671. https://doi.org/10.1038/s41467-023-38188-z.
  30. Shofa M, Ohkawa A, Okabayashi T, Kaneko Y, Saito A*. Development of a direct duplex real-time PCR assay for rapid detection of domestic cat hepadnavirus. J Vet Diagn Invest. 2023;35(2):139-144. https://doi.org/10.1177/10406387231154610.
  31. Kimura I, Yamasoba D, Nasser H, Zahradnik J, Kosugi Y, Wu J, Nagata K, Uriu K, Tanaka YL, Ito J, Shimizu R, Tan TS, Butlertanaka EP, Asakura H, Sadamasu K, Yoshimura K, Ueno T, Takaori-Kondo A, Schreiber G; Genotype to Phenotype Japan (G2P-Japan) Consortium; Toyoda M, Shirakawa K, Irie T, Saito A*, Nakagawa S, Ikeda T, Sato K. The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant. iScience. 2022;25(12):105720. https://doi.org/10.1016/j.isci.2022.105720.
  32. Morizako N, Butlertanaka EP, Tanaka YL, Shibata H, Okabayashi T, Mekata H, Saito A*. Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector. Sci Rep. 2022;12(1):16952. https://doi.org/10.1038/s41598-022-20970-6.
  33. Shofa M, Okamura T, Urano E, Matsuura Y, Yasutomi Y, Saito A*. Repeated Intravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge. Int J Mol Sci. 2022; 23（22）. https://doi.org/10.3390/ijms232214002
  34. Kaneko C, Saito A, Inagaki H, Sugiyama H, Mazimpaka E, Fujimoto S, Okabayashi T. Rapid inactivation of Dabie bandavirus （SFTSV） by irradiation with deep-ultraviolet light-emitting diode. J Med Virol. 2022; 94（7）:3438-3441. https://doi.org/10.1002/jmv.27698
  35. Saito A#, Tamura T, Zahradnik J, Deguchi S, Tabata K, Anraku Y, Kimura I, Ito J, Yamasoba D, Nasser H, Toyoda M, Nagata K, Uriu K, Kosugi Y, Fujita S, Shofa M, Begum MM, Shimizu R, Oda Y, Suzuki R, Ito H, Nao N, Wang L, Tsuda M, Yoshimatsu K, Kuramochi J, Kita S, Sasaki-Tabata K, Fukuhara H, Maenaka K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Ueno T, Schreiber G, Takaori-Kondo A, Shirakawa K, Sawa H, Irie T, Hashiguchi T, Takayama K, Matsuno K, Tanaka S, Ikeda T, Fukuhara T, Sato K. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant. Cell Host Microbe. 2022; 30（11）:1540-1555.e15. https://doi.org/10.1016/j.chom.2022.10.003
  36. Meng B, Abdullahi A, Ferreira IATM, Goonawardane N, Saito A#, et al. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity. Nature. 2022; 603（7902）:706-714. https://doi.org/10.1038/s41586-022-04474-x
  37. Saito A#, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature. 2022; 602（7896）:300-306. https://doi.org/10.1038/s41586-021-04266-9
  38. Inagaki H, Goto Y, Sugiyama H, Saito A, Okabayashi T, Watanabe K, Fujimoto S. Usefulness of a new DUV-LED device for the control of infection by Escherichia coli, Staphylococcus aureus, mycobacteria and spore-forming bacteria. Front Public Health. 2022;10:1053729. https://doi.org/10.3389/fpubh.2022.1053729.
  39. Ode H, Saito A#, Washizaki A, Seki Y, Yoshida T, Harada S, Ishii H, Shioda T, Yasutomi Y, Matano T, Miura T, Akari H, Iwatani Y. Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques. J Gen Virol. 2022;103(10). https://doi.org/10.1099/jgv.0.001790.
  40. Nasser H, Shimizu R, Ito J; Genotype to Phenotype Japan (G2P-Japan) Consortium; Saito A, Sato K, Ikeda T. Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay. STAR Protoc. 2022;3(4):101773. https://doi.org/10.1016/j.xpro.2022.101773.
  41. Kimura I, Yamasoba D, Tamura T, Nao N, Suzuki T, Oda Y, Mitoma S, Ito J, Nasser H, Zahradnik J, Uriu K, Fujita S, Kosugi Y, Wang L, Tsuda M, Kishimoto M, Ito H, Suzuki R, Shimizu R, Begum MM, Yoshimatsu K, Kimura KT, Sasaki J, Sasaki-Tabata K, Yamamoto Y, Nagamoto T, Kanamune J, Kobiyama K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Shirakawa K, Takaori-Kondo A, Kuramochi J, Schreiber G, Ishii KJ; Genotype to Phenotype Japan (G2P-Japan) Consortium; Hashiguchi T, Ikeda T, Saito A*, Fukuhara T, Tanaka S, Matsuno K, Sato K. Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5. Cell. 2022;185(21):3992-4007.e16. https://doi.org/10.1016/j.cell.2022.09.018.
  42. Shofa M, Kaneko Y, Takahashi K, Okabayashi T, Saito A*. Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health? Front Microbiol. 2022;13:938154. https://doi.org/10.3389/fmicb.2022.938154.
  43. Yamasoba D, Kimura I, Nasser H, Morioka Y, Nao N, Ito J, Uriu K, Tsuda M, Zahradnik J, Shirakawa K, Suzuki R, Kishimoto M, Kosugi Y, Kobiyama K, Hara T, Toyoda M, Tanaka YL, Butlertanaka EP, Shimizu R, Ito H, Wang L, Oda Y, Orba Y, Sasaki M, Nagata K, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Kuramochi J, Seki M, Fujiki R, Kaneda A, Shimada T, Nakada TA, Sakao S, Suzuki T, Ueno T, Takaori-Kondo A, Ishii KJ, Schreiber G; Genotype to Phenotype Japan (G2P-Japan) Consortium; Sawa H, Saito A*, Irie T, Tanaka S, Matsuno K, Fukuhara T, Ikeda T, Sato K. Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. Cell. 2022;185(12):2103-2115.e19. https://doi.org/10.1016/j.cell.2022.04.035.
  44. Sano E, Suzuki T, Hashimoto R, Itoh Y, Sakamoto A, Sakai Y, Saito A, Okuzaki D, Motooka D, Muramoto Y, Noda T, Takasaki T, Sakuragi JI, Minami S, Kobayashi T, Yamamoto T, Matsumura Y, Nagao M, Okamoto T, Takayama K. Cell response analysis in SARS-CoV-2 infected bronchial organoids. Commun Biol. 2022;5(1):516. https://doi.org/10.1038/s42003-022-03499-2.
  45. Okamoto N, Saito A, Okabayashi T, Komine A. Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2. J Oral Maxillofac Surg Med Pathol. 2022;34(6):800-804. https://doi.org/10.1016/j.ajoms.2022.04.001.
  46. Sugamoto K, Tanaka YL, Saito A, Goto Y, Nakayama T, Okabayashi T, Kunitake H, Morishita K. Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes. Biochem Biophys Res Commun. 2022;615:56-62. https://doi.org/10.1016/j.bbrc.2022.04.072.
  47. Takahashi K, Kaneko Y, Shibanai A, Yamamoto S, Katagiri A, Osuga T, Inoue Y, Kuroda K, Tanabe M, Okabayashi T, Naganobu K, Minobe I, Saito A*. Identification of domestic cat hepadnavirus from a cat blood sample in Japan. J Vet Med Sci. 2022;84(5):648-652. https://doi.org/10.1292/jvms.22-0010.
  48. Tanaka T, Saito A, Suzuki T, Miyamoto Y, Takayama K, Okamoto T, Moriishi K. Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening. Antiviral Res. 2022;199:105268. https://doi.org/10.1016/j.antiviral.2022.105268.
  49. Kimura I, Kosugi Y, Wu J, Zahradnik J, Yamasoba D, Butlertanaka EP, Tanaka YL, Uriu K, Liu Y, Morizako N, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Tokunaga K, Ueno T, Takaori-Kondo A, Schreiber G, Arase H; Genotype to Phenotype Japan (G2P-Japan) Consortium; Motozono C, Saito A, Nakagawa S, Sato K. The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance. Cell Rep. 2022;38(2):110218. https://doi.org/10.1016/j.celrep.2021.110218.
  50. Saito A, Yamashita M. HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules. Retrovirology. 2021;18(1):32. https://10.1186/s12977-021-00577-x.
  51. Oba M, Rongduo W, Saito A, Okabayashi T, Yokota T, Yasuoka J, Sato Y, Nishifuji K, Wake H, Nibu Y, Mizutani T. Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro. Biochem Biophys Res Commun. 2021;570:21-25. https://doi.org/10.1016/j.bbrc.2021.07.034.
  52. Saito A*, Shofa M, Ode H, Yumiya M, Hirano J, Okamoto T, Yoshimura SH. How Do Flaviviruses Hijack Host Cell Functions by Phase Separation? Viruses. 2021;13(8):1479. https://doi.org/10.3390/v13081479.
  53. Ferreira IATM, Kemp SA, Datir R, Saito A, Meng B, Rakshit P, Takaori-Kondo A, Kosugi Y, Uriu K, Kimura I, Shirakawa K, Abdullahi A, Agarwal A, Ozono S, Tokunaga K, Sato K, Gupta RK; CITIID-NIHR BioResource COVID-19 Collaboration, Indian SARS-CoV-2 Genomics Consortium; Genotype to Phenotype Japan (G2P-Japan) Consortium. SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion. J Infect Dis. 2021;224(6):989-994. https://doi.org/10.1093/infdis/jiab368.
  54. Yoshida T, Takemoto H, Sakamaki T, Tokuyama N, Hart J, Hart T, Dupain J, Cobden A, Mulavwa M, Hashimoto C, Isaji M, Kaneko A, Enomoto Y, Sato E, Kooriyama T, Miyabe-Nishiwaki T, Suzuki J, Saito A, Furuichi T, Akari H. Prevalence of antibodies against human respiratory viruses potentially involving anthropozoonoses in wild bonobos. Primates. 2021; 62(6):897-903. https://doi.org/10.1007/s10329-021-00935-5
  55. Inagaki H, Saito A, Kaneko C, Sugiyama H, Okabayashi T, Fujimoto S. Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device. Pathogens. 2021;10(6):754. https://doi.org/10.3390/pathogens10060754.
  56. Motozono C, Toyoda M, Zahradnik J, Saito A, Nasser H, Tan TS, Ngare I, Kimura I, Uriu K, Kosugi Y, Yue Y, Shimizu R, Ito J, Torii S, Yonekawa A, Shimono N, Nagasaki Y, Minami R, Toya T, Sekiya N, Fukuhara T, Matsuura Y, Schreiber G; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ikeda T, Nakagawa S, Ueno T, Sato K. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. Cell Host Microbe. 2021;29(7):1124-1136.e11. https://doi.org/10.1016/j.chom.2021.06.006.
  57. Fahkrajang W, Sudaryatma PE, Mekata H, Hamabe S, Saito A, Okabayashi T. Bovine respiratory coronavirus enhances bacterial adherence by upregulating expression of cellular receptors on bovine respiratory epithelial cells. Vet Microbiol. 2021;255:109017. https://doi.org/10.1016/j.vetmic.2021.109017.
  58. Kirino Y, Ishijima K, Miura M, Nomachi T, Mazimpaka E, Sudaryatma PE, Yamanaka A, Maeda K, Sugimoto T, Saito A, Mekata H, Okabayashi T. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Small-Animal Veterinarians and Nurses in the Japanese Prefecture with the Highest Case Load. Viruses. 2021;13(2):229. https://doi.org/10.3390/v13020229.
  59. Matsuoka S, Kuwata T, Ishii H, Sekizuka T, Kuroda M, Sano M, Okazaki M, Yamamoto H, Shimizu M, Matsushita S, Seki Y, Saito A, Sakawaki H, Hirsch VM, Miura T, Akari H, Matano T. A Potent anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Rhesus Macaques. J Virol. 2021;95(7):e02455-20. https://doi.org/10.1128/JVI.02455-20.
  60. Sudaryatma PE, Saito A, Mekata H, Kubo M, Fahkrajang W, Mazimpaka E, Okabayashi T. Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor. Front Microbiol. 2020;11:1676. https://doi.org/10.3389/fmicb.2020.01676.
  61. Inagaki H, Saito A, Sugiyama H, Okabayashi T, Fujimoto S. Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation. Emerg Microbes Infect. 2020; 9（1）:1744-1747. https://doi.org/10.1080/22221751.2020.1796529
  62. Sultana T, Mamede JI, Saito A#, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ, Shioda T. Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid. J Virol. 2019; 93（23）:e00986-19. https://doi.org/10.1128/JVI.00986-19
  63. Shimizu H, Saito A#, Mikuni J, Nakayama EE, Koyama H, Honma T, Shirouzu M, Sekine SI, Shioda T. Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. PLoS Negl Trop Dis. 2019; 13（11）:e0007894. https://doi.org/10.1371/journal.pntd.0007894
  64. Suzuki K, Phadungsombat J, Nakayama EE, Saito A, Egawa A, Sato T, Rahim R, Hasan A, Lin MY, Takasaki T, Rahman M, Shioda T. Genotype replacement of dengue virus type 3 and clade replacement of dengue virus type 2 genotype Cosmopolitan in Dhaka, Bangladesh in 2017. Infect Genet Evol. 2019; 75:103977. https://doi.org/10.1016/j.meegid.2019.103977
  65. Suzuki K, Nakayama EE, Saito A, Egawa A, Sato T, Phadungsombat J, Rahim R, Hasan A, Iwamoto H, Rahman M, Shioda T. Evaluation of novel rapid detection kits for dengue virus NS1 antigen in Dhaka, Bangladesh, in 2017. Virol J. 2019; 16（1）:102. https://doi.org/10.1186/s12985-019-1204-y
  66. Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing. J Virol. 2019; 93（16）:e00706-19. https://doi.org/10.1128/JVI.00706-19
  67. Saito A*, Ode H, Nohata K, Ohmori H, Nakayama EE, Iwatani Y, Shioda T. HIV-1 is more dependent on the K182 capsid residue than HIV-2 for interactions with CPSF6. Virology. 2019; 532:118-126. https://doi.org/10.1016/j.virol.2019.04.012
  68. Fischer DK, Saito A, Kline C, Cohen R, Watkins SC, Yamashita M, Ambrose Z. CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes. J Virol. 2019; 93（9）:e00214-19. https://doi.org/10.1128/JVI.00214-19
ENGLISHへ戻る