Research Overview
Our research group is dedicated to uncovering the intricate interactions between viruses and their hosts, bridging fundamental science and applied research. Despite their microscopic size, viruses have evolved sophisticated strategies to evade immune responses, manipulate host physiology, and even cross species barriers. By dissecting these mechanisms at the molecular level, we aim to contribute not only to the prevention, diagnosis, and treatment of infectious diseases but also to a broader understanding of life sciences.
At the core of our work is a unique approach that integrates veterinary medicine with molecular virology. We focus particularly on zoonotic and emerging viruses, including domestic cat hepatitis B virus (DCHBV), HIV-1 and simian-tropic HIV-1, Zika virus (ZIKV), Venezuelan equine encephalitis virus (VEEV), and severe fever with thrombocytopenia syndrome virus (SFTSV). To study these viruses, we employ cutting-edge techniques such as CRISPR/Cas9 genome editing, next-generation sequencing (NGS), reverse genetics, reporter virus systems, and infection models using mice and non-human primates.
For example, our work on DCHBV has shed light on its genetic diversity, transmission routes, and possible association with liver cancer in cats, providing new insights into veterinary virology. In HIV-1 research, we are developing simian-tropic HIV-1 variants to study host restriction factors and immune responses in macaques, which may pave the way for future vaccine and therapeutic development. Our ZIKV studies involve the use of AG129 mice and reporter viruses to establish a congenital microcephaly model, helping us investigate the mechanisms behind fetal brain development disorders. In addition, we are actively engaged in the development of novel animal cell lines to improve virus isolation efficiency—research that directly supports rapid diagnostics and therapeutic evaluation in clinical and field settings.
Our laboratory is also committed to international collaboration. We are actively working with research institutions in the UK, France, Indonesia, and Taiwan, tailoring joint projects to the regional characteristics of viral infections. With our partners in the UK and France, we are investigating the molecular mechanisms of HIV and DCHBV infection and developing new antiviral strategies. In collaboration with Indonesian institutions, we are conducting epidemiological studies and fieldwork focused on livestock viruses, while also developing surveillance and control technologies. Our joint research with Taiwan aims to understand the current epidemiology of DCHBV and establish improved diagnostic tools. Through these global partnerships, we aim to exchange diverse perspectives and technologies, contributing to international infectious disease control efforts.
Fostering the next generation of scientists is another key mission of our lab. We actively encourage young researchers to participate in international research projects and overseas training programs to broaden their global outlook. Our lab brings together students and researchers from diverse backgrounds who engage in collaborative work and open discussions, valuing creativity, mutual respect, and shared expertise.
We warmly welcome passionate individuals who wish to take on the challenge of studying emerging viruses and contribute to the health and safety of our global community. The knowledge and skills developed in our lab will not only advance academic research but also have meaningful impact on society at large. We look forward to working with you.
Akatsuki Saito