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2010  
月日 担当者 タイトル
1月20日 宮原

Gong D, Chen X, Middleditch M, Huang L, Amarsingh GV, Reddy S, Lu J, Zhang S, Ruggiero K, Phillips AR, Cooper GJ: Quantitative proteomic profiling identifies new resnal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats. Proteomics 9: 4309-4320, 2009

1月13日 重村

Cybulsky AV. Endoplasmic reticulum stress in proteinuric kidney disease. Kidney Int. 2010; 77: 187-193.

12月22日 東島

Kim J, William WJ, James K, Tisher CC, Madsen KM: Immunocytochemical response of type A and type B intercalated cells to increased sodium chloride delivery. Am J Physiol Renal Physiol 262: F288-F302, 1992

12月9日 西村

Sammels E, Devogelaere B, Mekahli D, Bultynck G, Missiaen L, Pary JB, Cai Y, Somlo S, De Smedt H: Polycystin-2 activation by inositol 1,4,5-trisposphate-induced Ca2+release requires its direct association with the inositol 1,4,5-triphosphate receptor in a signaling microdomain. J Biol Chem 285: 18794-18805, 2010

11月30日 園田

Zwang NA, Hoffert JD, Pisitkun T, Moeller HB, Fenton RA, Knepper MA. Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry. J. Proteome Res 2009; 8(3): 1540-1554.

11月25日 池田

Aquaporin-1 function is regulated by protein kinase C
1. Zhang W, Zitron E, Homme M, Kihm L, Morath C, Scherer D, Hegge S, Thomas D, Schmitt CP, Zeier M, Katus H, Karle C, Schwenger V. 2007. Aquaporin-1 channel function is positively regulated by protein kinase C.J Biol. Chem. 282: 20933-20940.
2. Conner, M.T., Conner, A.C., Brown, J.E., Bill, R.M. 2010. Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity. Biochemistry. 49: 821-823.

11月11日 髙橋

Yoo, K.H., Kim, Y.N., Lee, M.J., Seong, J.K., Park, J.H. Identification of apolipoproteinA1 reduction in the polycystic kidney by proteomics analysis of the Mxi1-deficient mouse. Proteomics. 2009, 9: 3824-3832.

10月13日 宮原

Miller EW, Dickinson BC, Chang CJ: Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci U S A 107: 15681-15686, 2010

10月21日 重村

Hara, M., Yanagihara, T., Hirayama, Y., Ogasawara, S., Kurosawa, H., Sekine, S., Kihara, I. 2010. Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli. Hum. Pathol. 41: 1265-1275.

10月14日 東島

Rood IM, Deegens JK, Merchant ML, Tamboer WP, Wilkey DW, Wetzels JF, Klein JB.Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome. Kidney Int 2010; 78: 810-816.

10月 7日 西村

Li Y, Santoso NG, Yu S, Woodward OM, Qian F, Guggino WB. Polycystin-1 interacts with inositol 1,4,5-trisphosphate reseptor to modurate intracellular Ca2+ signaling with implications for polycystic kidney disease. J Biol Chem 284: 36431-36441, 2009

8月19日 松下

Hamdi, M., Sanchez, MA., Beene, LC., Liu, Q., Landfear, SM., Rosen, BP., Liu, Z. 2009. Arsenic transport by zebrafish aquaglyceroporins. BMC Mol. Biol. doi:10.1186/1471-2199-10-104.

8月 9日 磯見

Golab, F., Kadkhodaee, M., Zahmatkesh, M., Hedayati, M., Arab, H., Schuster, R., Zahedi, K., Lentsch, A. B., Soleimani, M. Ischemic and non-ischemic acute kidney injury cause hepatic damage. Kidney Int 2009; 75: 783-792

8月 6日 牟田

Wang, T., Huang, Y., Wang, J., Cheng, C., Huang, W., Lu, P., Xu, Y., Wang, P., Yan, N., Shi, Y. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature 462, 467-472(2009).

7月21日 高橋

Lam, L., Tsoutsman, T., Arthur, J., Semsarian, C. Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy. J. mol. Cell. Cardiol. 2010, 48 1014-1022.

7月12日 園田

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B and Simons M. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319: 1244-1247, 2008.

6月30日 宮原

Carbrey JM, Song L, Zhou Y, Yoshinaga M, Rojek A, Wang Y, Liu Y, Lujan HL, DiCario SE, Nielsen S, Rosen BP, Agre P, Mukhopadhyay R: Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. Proc Natl Acad Sci U S A 106: 15956-15960, 2009.

6月23日 東島

Gabbi C, Kim HJ, Hultenby K, Bouton D, Toresson G, Warner M, Gustafasson JA: Pancreatic exocrine insufficiency in LXRβ-/- mice is associated with a reduction in aquaporin-1 expression. Proc Natl Acad Sci USA 105: 15052-15057, 2008.

6月23日 重村

Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva-Nilsson L, Breakefield XO: Prostate cancer-derived urine exosomes: a nobel approach to biomarkers for prostate cancer. Br J Cancer 100: 1603-1607, 2009.

6月 9日 西村

Crane JM, Benett JL, Verkman AS: Live cell analysis of aquaporin-4 M1/M23 interactions and regulated orthogonal array assembly in glial cells. J Biol Chem 284: 35850-35860, 2009

6月 7日 池田

PKD原因タンパク質であるpolycystin-2のcoiled coilモチーフの意義
Giamarchi, A., Feng, S., Rodat-Despoix, L., Xu, Y., Bubenshchikova, E., Newby, L.J., Hao, J., Gaudioso, C., Crest, M., Lupas, A.N., Honore, E., Williamson, MP., Obara, T., Ong, A.C,, Delmas P.2010. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.EMBO J.29:1176-1191.

6月 2日 牟田

Sorani, M. D., Zador, Z., Hurowitz, E, Yan, D., Giacomini, K. M., Manley, G. T. (2008) Novel variants in human Aquaporin-4 reduce cellular water permeability. Novel variants in human Aquaporin-4 reduce cellular water permeability.

5月26日 松下

Tigaud-Seqeura, A., Calusinska, M., Finn, RN., Chauvigne, F., Lozano, J., Cerda, J. 2010. The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals. BMC Evol Biol. 2010, 10:38.

5月19日 磯見

Pisitkun, T., Bieniek, J., Tchapyjnikov, D., Wang, G., Wu, W. W., Shen, R. F., Knepper, M. A. High-throughput identification of IMCD proteins using LC-MS/MS. Physiol Genomics 25: 263-276,2006.

5月12日 近藤

Sheen MR, Kim JA, Lim SW, Jung JY, Han KH, Jeon US, Park SH, Kim J, Kwon HM.2009 Interstitial tonicity controls TonEBP expression in the renal medulla. Kidney Int. 75:518-25.

4月28日 髙橋

Aregger, F., Pilop, C., Uehlinger, D.E, Brunisholz, R., Carrel, T.P., Frey, F.J., and Frey, B.M. Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury. J Thorac Cardiovasc Surg. 2010; 139: 692-700

4月21日 池田

The secretory mechanism of circulating microRNAs
Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. 2010. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem. 4;285(23):17442-52.

4月16日 園田

Fernandez-Llama P, Khositseth S, Gonzales PA, Star RA, Pisitkun T, Knepper MA. Tamm-Horsfall protein and urinary exosome isolation. Kidney Int 2010; 77: 736-742.