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2025  
月日 担当者 Paper
1月15日 森脇

Ware AW, Rasulov SR, Cheung TT, Lott JS, McDonald FJ. Membrane trafficking pathways regulating the epithelial Na+ channel. Am J Physiol Renal Physiol. 2020;318(1):F1-F13 doi:10.1152/ajprenal.00277.

1月15日 谷次

Chiumello D, Aiello C, Pozzi T, Panina F, Muscas A, Mancusi S, Coppola S. Effect of mannitol on diuresis and acid–base equilibrium in critically ill patients. Intensive Care Med Exp. 2025;13: 96 doi: 10.1186.s40635-025-00807-y.

1月8日 大𠮷

Wang W, Tai S, Cheng X, Yang L, Chang Y, Yan J, Tao J, Zhou J. Protective rple of exosomoes in renal ischemia-reperfusin injury: a systematic review and meta-analysis. Front Pharmacol. 2025; 16:1653907 doi:10.3389/fphar.2025.1653907.

1月8日 高野

Kikuchi H, Chou CL, Yang CR, Chen L, Jung HJ, Park E, Limbutara K, Carter B, Yang ZH, Kun JF, Remaley AT, Knepper MA. Signalingmechanismsinrenalcompensatory hypertrophy revealed by multi-omics. Nat Commun. 2023 14(1):3481 doi: 10.1038/s41467-023-38958-9.

12月11日 アリフ

Chen K, Xu B, Qiu S, Long L, Zhao Q, Xu J, Wang H. Inhibition of phosphodiesterase 4 attenuates aquaporin4 expression and astrocyte swelling following cerebralischemia/reperfusion injury. Glia 72:1629-1645, 2024. doi:10.1002/glia.24572

12月4日 ナターシャ

Kano Y, Yamaguchi S, Mise K, Kawakita C, Onishi Y, Kurooka N, Sugawara R, Albuayjan HHH, Nakatsuka A, Eguchi J, Wada J: Inhibition of amino acids influx into proximal tubular cells improves lysosome function in diabetes. Kidney360. 2024;5;182-194. doi:10.34067/KID.0000000000000333

11月28日 アピサダー

Ganeshkumar Rajendran, Michael P. Schonfeld, Ratnakar Tiwari, Shengping Huang, Rafael Torosyan, Timothy Fields, Jihwan Park, Katalin Susztak, Pinelopi P. Kapitsinou. Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1. JASN. 2020;31(3):501-516. doi:10.1681/ASN.2019050523

11月20日  ニラ 

Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, Hori M, Ozaki H. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via a7nACh receptors on muscularis macrophages associated with postoperative ileus. Gut. May 2011; doi:10.1136/gut.2010.227546 

11月13日  園田(紘) 

Prasad D, Drysch A, Upadhyay D, Neilson EG:The story of aldosterone escape. J Am Soc Nephrol. 2025;00:1-8. doi: 10.1681/ASN. 0000000908. 

11月13日  東島 

Fu Y, Ding X, Zhang M, Feng C, Yan Z, Wang F, Xu J, Lin X, Ding X, Wang L, Fan Y, Li T, Yin Y, Liang X, Xu C, Chen S, Pulous FE, Gennert D, Pun FW, Kamya P, Ren F, Aliper A, Zhavoronkov A. Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor. Nat Biotechnol. Dec 11 2024; doi:10.1038/s41587-024-02503-w 

10月17日 池田

1. Ma J, Zhou C, Yang J, Ding X, Zhu Y, Chen X: Expression of AQP6 and AQP8 in epithelial ovarian tumor. J Mol Histol 47: 129-134, 2016
2. Yamamoto E, Joo K, Lee J, Sansom MSP, Yasui M: Molecular mechanism of anion permeation through aquaporin 6. Biophys J 123: 2496-2505, 2024

 10月9日 園田(美)

Potteti HR, Noone PM, Tamatam CR, Ankireddy A, Noel S, Rabb H, Reddy S. Nrf2 mediates hypoxia-inducible HIF1a activation in kidney tubular epithelialcells. Am J Physiol Renal Physiol. 2021; 320: F464-f74 doi:10.1152/ajprenal. 00501. 2020 

10月9日 神﨑

Rios-Szwed DO, Alvarez V, Sanchez-Pulido L, Garcia-Wilson E, Jiang H, Bandau S, Lamond A, Alabert C: FAM111A regulates replication origin activation and cell fitness. Life Sci Alliance. 2023;6(12):2023-2111 doi:10.26508/lsa.202302111.

8月18日 園田(美) 

Liao X, Lv X, Zhang Y, Han Y, Li J, Zeng J: Fluorofenidone inhibits UUO/IRI-induced renal fibrosis by reducing mitochondrial damage. Oxid Med Cell Longev. 2022; 2022:2453617 doi:10.1155/2022/2453617 

 7月22日 森脇

Yunzhou F, Haoxun W, Zhou Y, Zhengxuan L, Yufan L, Guofeng Y. Inhibition of Proteasome, but not Lysosome, Upregulates Organic Anion Transporter 3 in vitro and in vivo. Biochem Pharmcol. 2023; 208:115387 doi:10.1016/j.bcp.2022.115387

7月10日   大𠮷

Xu J, Hu Z, Dai L, Yadav A, Jiang Y, Broer A, Gardiner MG, McLeod M, Yan R, Broer S: Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19). Nat Commun. 2024;15(1):7224. doi:10.1038/s41467-024-51748-1

7月10日   高野

Wobst HJ, Viader A, Muncipinto G, Hollibaugh R, van Kalken D, Burkhart CT, Cantin SM, Bates RM, Regimbald-Dumas Y, Gross L, Antalek MT, Zweig JE, Wu F, Rettenmaier TJ, Labenski MT, Pullen N, Blanchette HS, Henderson JL, Weng HH, Vaughn TA, Brown DG, Throup JP, Barrish JC. FSLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine. JCI Insight. 2024 Nov 8;9(21):e182876 doi:10.1172/jci. insight. 182876.

7月5日  谷次

Vallon V. Glucose transporters in the kidney in health and disease. Pflugers Arch. 2020; 472(9):1345-1370 doi: 10.1007/s00424-020-02361-w

6月26日 神﨑

Kojima Y, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ: FAM111A protects replication forks from protein obstacles via its trypsin-like domain. Nat Commun 2020; 11(1): 13-18 doi:10.1038/s41467-020-15170-7

5月29日 Apisada

Zhou M, Hou J, Li Y, Mou S, Wang Z, Horch RE, Sun J, Yuan Q: The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model. Sci Rep, 9(1):6035, 2019 doi:10.1038/s41598-019-41924-5

5月22日 Natasha

Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Jensen BL, Palmer LA, Carey RM, Sung S-SJ, Malakauskas SM, Isakson BE, Le TH: Loss of collectrin an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and cause hypertensin and vascular dysfunction. Circulation, 128(17): 1770-1780, 2013 doi:10.1161/CIRCULATIONAHA.113.003301

5月8日 Nilla

Giancola F, Rambaldi AM, Bianco F, Iusco S, Romagnoli N, Tagliavia C, Bombardi C, Clavenzani P, De Giorgio R, Chiocchetti R: Localization of the 5-hydroxytryptamine 4 receptor in equineenteric neurons and extrinsic sensory fibers. Neurogastroenterol Motil, 29: e13045, 2017

5月1日 東島

Tiwari R, Sharma R, Rajendran G, Borkowski GS, An SY, Schonfeld M, O'Sullivan J, Schipma MJ, Zhou Y, Courbon G, Thomson BR, David V, Quaggin SE, Thorp EB, Chandel NS, Kapitsinou PP: Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis. J Clin Invest, 135, 2024 doi:10.1172/JCI176207

4月24日 園田(紘)

Tough IR, Lund ML, Patel BA, Schwartz TW, Cox HM: Paracrine relationship between incretin hormones and endogenous 5- hydroxytryptamine in the small and large intestine. Neurogastroenterol Motil, 35: e14589, 2023

4月17日 池田

Devuyst O: Aquaporin-1 and osmosis: From physiology to precision in peritoneal dialysis. J Am Soc Nephrol 35: 1589-1599, 2024