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2026  
月日 担当者 Paper
11月11日 Natasha

Chen Z, Duan R, Chen Z, et al. ASLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1. Oncogenesis, 2025;14-38. doi:10.1038/s41389-025-0058-3.

11月5日 Nilla

Musovic S, Olofsson CS. Adrenergic stimulation ofadiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity. Sci Rep, 9:10680, 2019. doi:10.1038/s41598-019-47113-8.

10月29日 東島

Choueiri TK, Merchán J, Patnaik A, Drakaki A, Rini BI, Rha SY, Lee JL, Ornstein MC, Kumar R, Hwang C, Shao Y, Park SH, Barata PC, McGregor BA, Foster P, Chen J, Eisen M, Cole H, Weeder B, Guan Y, Singh J, Kaplan A, Cho S, Markus R, Kabbarah O, McKay RR. Casdatifan shows durable response linked to HIF-2α biology in kidney cancer. Nature. 656:734-741, 2026 doi: 10.1038/s41586-026-10718-x.

10月15日 園田

Wulfmeyer VC, Gernemann M, de la Rosa X, Kristensen AM, Berg P, Xiong L, Kretz O, Fiedler IAK, Jaegers J, Billing AM, Bøgh N, Hoyer-Allo J, Grundmann F, Burst V, Laustsen C, Schiessl IM, Müller RU, Demir F, Rinschen MM. Perifusate metabolomics interrogates nutrient exposure and oxidative stress response in kidney tubules. Cell Rep. 2026;45(9):117963 doi: 10.1016/j.celrep.2026.117963.

10月7日 池田

Ghasemi A, Jeddi S, Kashfi K: Mammalian nitrate transport: emerging roles of sialin, chloride channels, aquaporin-6, and the sodium-iodide symporter. Biochem Pharmacol 254:118412, 2026. doi.org/10.1016/j.bcp.2026.118412

9月30日 森脇

Babicz RSE, Baylor N, Terlouw A, Faber DA, Fukushima K, Biondi RM, Bouley R, Brown D. Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation andmembrane accumulation after EGFR inhibition with erlotinib. Am J Physiol Renal Physiol. 2025;328(3):F344-F359. doi:10.1152/ajprenal.00353.2024

9月30日 谷次

Hunter RW, Ivy JR, Bailey MA. Glucocorticoids and renal Na+ transport: implicationsfor hypertensionandsaltsensitivity. J Physiol 2014;592(8):1731-1744, doi: 10.1113/jphysiol.2013.267609

7月23日 関矢

Lewis S, Chen L, Raghuram V, Khundmiri SJ, Chou C, Yang C, Knepper AM. "SLC-omics" of the kidney: solute transporters along the nephron. Am J Cell Physiol. 2021;321(3):C507-518 doi:10.1152/ajpcell.00197.2021

7月16日 永延

Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furfa G. Targeted degradation of SLC transporters reveals amenability of multi-pass transmembrane proteins to ligand-induced proteolysis. Cell Cham Biol. 2020;27(6):728-739.e9.: 10.1016/j.chemibiol.2020.04.003

7月9日 高野

Navarro GA, Kin YC, Oe Y, Zhang H, Crespo-Masip M, Goodluck HA, Kanoo S, Sanders PW, Broer S, Vallon V. Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutralamino acid transporter B 0 AT1 (Slc6a19). Am J Physiol Renal Physiol. 2022;323(4):F455-F467. doi:10.1152/ajprenal.00181.2022.

7月2日 森脇

Kharin A, Klussmann E. Many kinases for controlling the water channelaquaporin-2. J Physiol. 2023;602(13):3025-3039 doi:10.1113/JP284100.

6月25日 谷次

Chen M, Cai H, Klein JD, Laur O, Chen G. Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions. Front Physiol. 2015;6:310. doi:10.3389/fphys.2015.00310

5月28日 Natasha

Alkhofash NF, Ali BR: Hartnup disease-causing SLC6A19 mutations lead to B0AT1 aberrant trafficking and ACE2 mis-localisation implicating the endoplasmic reticulum protein quality control. Front Cell Dev Bio 13: 1589534, 2025. doi:10.3389/fcell.2025.1589534.

5月21日 Arif

He L, Zhang Q, Sheng X, Yin J, Yan Y, Wu M, et al. Loss of ARNTL Enhances ER Stress and Apoptosis in CKD Through Disruption of NRF2 Signaling. FASEB J. 2025;39(11):e70715. doi: 10.1096/fj.202403398RRR.

5月14日 Nilla

Cheng Y, Kou Y, Wang J, Wang Y, Rong W, Han H, Zhang G. 5-Hydroxytryptamine 4 Receptor Agonist Attenuates Diabetic Enteric Neuropathy through Inhibition of the Receptor-Interacting Protein Kinase 3 Pathway. Am J Pathol. May 2024;194(5):785-795. doi: 10.1016/j.ajpath..2024.01.006.

5月7日 東島

Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Mate M, Stoll C, Bottcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Bluml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Gruneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Kronke G. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. May 2024;629(8010):184-192.

4月23日 園田

Sekiguchi Y, Mori M, Maruyama H, Nakao Y, Kikuchi H, Mandai S, Ando F, Susa K, Mori T, Waseda Y, Yoshida S, Fujii Y, Shoda W, Takahashi D, Okazaki R, Ikeda K, Yamada T, Sohara E, Uchida S, Mori Y. The Pathophysiological Mechanism of Beni-koji Choleste-Help or Puberulic Acid–Induced Kidney Injury. Kidney Int Rep. 2026;11(4):103793. doi: 10.1016/j.ekir.2026.103793.

4月16日 池田

Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gamsevoort RT, Meijer E: Effects of hydrochlorothiazide and metformin on aquaresis and nephroprotection by a vasopressin V2 receptor antagonist in ADPKD: A randomized crossover trial. Clin J Am Soc Nephrol 17: 507-517, 2022
<参考>Jdiaa SS, Mustafa RA, Yu ASL:Treatment of autosomal-dominant polycystic kidney disease. Am J Kidney Dis 85: 491-200, 2025